Disrupting N-glycosylation using type I mannosidase inhibitors alters B-cell receptor signaling. Huang A, Kurhade SE, Ross P, Apley KD, Griffin JD, Berkland CJ, and Farrell MP. ACS Pharmacol Transl Sci., 2022, 5(11):1062-1069. PMID: 36407961
Lectin Drug Conjugates Targeting High Mannose N-Glycans. Kurhade SE, Ross P, Gao FP, Farrell MP. ChemBioChem., 2022, e202200266. doi: 10.1002/cbic.202200266. PMID: 35816406
Directing CAR NK cells via the metabolic incorporation of CAR ligands into malignant cell glycans. Antillón K, Ross P, Farrell MP. ACS Chem Biol., 2022, 17(6):1505-1512. PMID: 35648806
The Road to Structurally Defined b-Glucans. Ross P, Farrell MP. Chem. Rec. 2021;21(11): 3178-3193. PMID: 34010496.
Functionalized High Mannose-Specific Lectins for the Discovery of Type I Mannosidase Inhibitors. Kurhade SE, Weiner JD, Gao FP, Farrell MP. Angew. Chem. Int. Ed. 2021;60(22):12313-8. PMID: 33728787.
Prior to the University of Kansas
Zou S, Zhang S, Gaffney A, Ding H, Lu M, Grover JR, Farrell MP, Nguyen HT, Zhao C, Anang S, Zhao M, Mohammadi M, Blanchard SC, Abrams C, Madani N, Mothes W, Kappes JC, Smith AB 3rd, Sodroski J. Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins. J Virol. 2020 May 4;94(10). PMID: 32161177.
Zhao C, Princiotto AM, Nguyen HT, Zou S, Zhao ML, Zhang S, Herschhorn A, Farrell MP, Pahil K, Melillo B, Sambasivarao SV, Abrams C, Smith AB 3rd, Madani N, Sodroski JG. Strain-dependent Activation and Inhibition of Human Immunodeficiency Virus (HIV-1) Entry by a Specific PF-68742 Stereoisomer. J Virol. 2019, Oct 15;93(21) pii: e01197-17-19 PMID: 31391272.
Farrell MP, Doyle LM. Influence of acyl groups on glucopyranoside reactivity in Lewis acid promoted anomerisation. Tetrahedron letters. 2018 July; 56(28):2726. doi: 10.1016/j.tetlet.2018.05.076.
Herschhorn A, Gu C, Moraca F, Ma X, Farrell MP, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG. The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions. Nat Commun. 2017 Oct 19;8(1):1049. doi: 10.1038/s41467-017-01119-w. PubMed PMID: 29051495.
Farrell MP, Melillo B, Smith AB 3rd. Type II Anion Relay Chemistry: Exploiting Bifunctional Weinreb Amide Linchpins for the One-Pot Synthesis of Differentiated 1,3-Diketones, Pyrans, and Spiroketals. Angew Chem Int Ed Engl. 2016 Jan 4;55(1):232-5. PubMed PMID: 26586577.
Farrell MP, Zhou J, Murphy PV. Regiospecific anomerisation of acylated glycosyl azides and benzoylated disaccharides by using TiCl4. Chemistry. 2013 Oct 25;19(44):14836-51. Epub 2013 Sep 20. PubMed PMID: 24591217.
Breen EP, Pilgrim W, Clarke KJ, Yssel C, Farrell MP, Zhou J, Murphy PV, Porter RK. Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths. J Chem Biol. 2013 Mar 27;6(3):121-33. doi: 10.1007/s12154-013-0093-6. eCollection 2013 Mar 27. PubMed PMID: 24432128.
Gerlach JQ, Kilcoyne M, Farrell MP, Kane M, Joshi L. Differential release of high mannose structural isoforms by fungal and bacterial endo-β-N-acetylglucosaminidases. Mol Biosyst. 2012 Apr;8(5):1472-81. doi: 10.1039/c2mb05455h. Epub 2012 Feb 28. PubMed PMID: 22373601.
Kilcoyne M, Gerlach JQ, Farrell MP, Bhavanandan VP, Joshi L. Periodic acid-Schiff’s reagent assay for carbohydrates in a microtiter plate format. Anal Biochem. 2011 Sep 1;416(1):18-26. doi: 10.1016/j.ab.2011.05.006. Epub 2011 May 10. PubMed PMID: 21620792.
The Farrell Lab 